US science faces big chill

Big science, little science.

In the USA, where I live and work, it is well known that I have little love for structural genomics—the attempt to determine the structures of most or all of the proteins in an organism by some combination of high-throughput X-ray crystallo graphy, nuclear magnetic resonance spectroscopy and homology modelling. My reasons are a matter of public record: structural genomics is based on an assumpt...

Hypothermia in Organophosphate Compound Poisoning: Recognizing the Big Chill

references 1. Hatwalne MS. Free radical scavengers in anaesthesiology and critical care. Indian J Anaesth 2012;56:227‐33. 2. Pham‐Huy LA, He H, Pham‐Huy C. Free radicals, antioxidants in disease and health. Int J Biomed Sci 2008;4:89‐96. 3. Kikuchi K, Miura N, Kawahara KI, Murai Y, Morioka M, Lapchak PA, et al. Edaravone (Radicut), a free radical scavenger, is a potentially useful addition to t...

The Big Chill: The WTO and Multilateral Environmental Agreements*

If sustainable development is about the integration of economic and environmental goals, then there seems to be a signiacant lack of integration between the preeminent global governance structures set up to manage trade and environment respectively. The international trade regime has evolved into one of the most powerful and inouential multilateral regimes in the world today in terms of its abi...

Hypothermia in trauma patients: predicting the big chill

Physicians commonly ignore hypothermia, an often-underappreciated event associated with mortality in trauma patients, in general due to its prevalence and belief that it is secondary to the injury itself (secondary hypothermia). Over the past several decades, hypothermia in trauma has been studied concerning its effects on mortality; however, very little has been done to identify the major risk...

The big chill: diseases exacerbated by exposure to cold.